Abstract
Human eye colour is recognized as one of the visible characterized features that would be valuable for forensic identification by predicting these phenotypes with particular genotypes. Recent gene association study had figured the remarkable variants mainly in OCA2 and HERC2 genes. In this study, eight human eye colour single nucleotide polymorphisms (SNPs) in five pigmentation genes, OCA2 (rs7495174, rs4778241 and rs4778138), HERC2 (rs12913832 and rs1667394), SLC24A4 (rs12896399), SLC45A2 (rs16891982) and TYR (rs1393350) were investigated in 374 Thai samples. The homozygote genotypes were predominantly observed in rs16891982 (GG/0.9920), rs1393350 (GG/0.9973) and rs12913832 (AA/0.9866). The allele frequency comparison with other populations in HapMap had identified the major allele of East Asia and Thai. Furthermore, the analysis of haplotype block of HERC2-OCA2 comprised five SNPs (rs12913832, rs1667394, rs7495174, rs4778241 and rs4778138) presented the most haplotype was AG-GAG (0.5199), which was rarely observed in European population.
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