Abstract
Alginate hydrogel has plausible applications in drug delivery, wound dressing, and tissue regeneration due to its good gelation and biocompatibility properties. However, scaffolds fabricated from alginate hydrogels need more mechanical properties. Various researchers investigated improving the mechanical properties of alginate hydrogels with the addition of different natural and synthetic polymers. 3D bioprinting is an embryonic technology in the biomedical field for printing a variety of complex soft and hard tissues and organs. Extrusion-based bioprinting (EBBP) is widely used among the different methods for printing alginate hydrogels. The present review studies alginate hydrogels with a blend of natural and synthetic polymers, ceramics, and metals to improve biomechanical properties concerning different biomedical applications. Advancements in EBBP are elucidated for printing a variety of scaffolds and tissues using multimaterial alginate hydrogels. The application of machine learning is pondered for optimizing the composition of multimaterial alginate hydrogel. Additionally, the challenges and futuristic aspects are discussed to enhance bioconstruct properties.
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