Abstract
Abstract In various biomedical applications extrusion represents a common manufacturing process for polymeric semi-finished products. Extrusion allows the processing of a wide range of biomaterials, as well as different cross-sectional geometries. The present work focuses on the development of an extrusion process for polymer micro-tubes used for medical devices manufacturing, e.g. microstents for minimally invasive glaucoma therapy. Semi-finished products were manufactured by means of extrusion and dip-coating. Morphology was investigated using biaxial laser measurement and scanning electron microscopy (SEM). For the analysis of mechanical and thermal properties of the specimens uniaxial tensile testing and differential scanning calorimetry (DSC) were performed. While dip-coated micro-tubes reveal a smooth and homogeneous surface, SEM micrographs of extruded micro-tubes exhibit some longitudinal grooves. Mechanical properties of extruded and dip-coated micro-tubes are comparable, so that the presented extrusion process can be regarded suitable for the manufacturing of polymer microtubes in a sub-millimeter scale. A future improvement of nozzle design will allow for a smooth surface of extruded semi-finished products.
Highlights
Glaucoma represents the leading cause of irreversible blindness worldwide [1]
Therapeutic approaches are based on the lowering of intraocular pressure (IOP)
Glaucoma drainage devices are available in various sizes, materials and designs with or without an IOP regulating valve
Summary
Glaucoma represents the leading cause of irreversible blindness worldwide [1]. Therapeutic approaches are based on the lowering of intraocular pressure (IOP). Glaucoma drainage devices are available in various sizes, materials and designs with or without an IOP regulating valve. Extrusion is being investigated and evaluated as an alternative to dip-coating methods for the manufacturing of micro-tubes [3]. These two manufacturing processes for tubular semi-finished products as a basis for glaucoma drainage devices were compared. For this purpose, biodegradable polyL-lactide (PLLA) and non-biodegradable thermoplastic silicone-based polyurethane (ChronoSil) were fabricated
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