Abstract
T cell deficiency after bone marrow transplantation (BMT) leads to significant morbidity and mortality due to infection and malignant relapse. We have previously shown that CD4-CD8- T cell precursors (preT) generated via OP9-DL1 coculture improve thymic and peripheral T cell reconstitution when administered at the time of BMT. While the thymus supports T cell development into old age, adult BMT recipients have limited thymic function due to age-related involution and additional injury caused by transplant conditioning.
Full Text 
Sign-in/Register to access full text options
Sign-in/Register to access full text options 
Published version (
Free)
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
