Extrasystolic arrhythmia as a risk factor of atherosclerosis

Abstract

Abstract Funding Acknowledgements Type of funding sources: None. Aim To determine the relationship between hemodynamic changes in extrasystolic arrhythmia and atherosclerosis of main arteries. Materials and methods We included 286 patients (175 men and 111 women). The investigation was made to reveal the signs of atherosclerosis. All patients were performed 24-hours ECG monitoring, blood lipid spectrum, TTE, TOE, ultrasound doppler of brachiocephalic arteries, abdominal aorta branches, lower extremities arteries, renal arteries. If prescribed - stress Echo, coronary angiography, renal arteries angiography, pancerebral angiography. All patients were made apexcardiography (ACG) and arterial vessels sphygmography (SG) of aa. carotis, ulnaris, radialis, femoralis, tibialis posterior. The main parameters included speed, acceleration, power, work in each phase of cardiocycle. In accordance with amount of extrasystoles per 24 hours all the patients were divided into 2 groups: 1 – less than 3000 (144 patients), 2 – 3000 and more (142). They were grouped due to the age (see table 1 on the picture). Groups were common in age, sex, comorbidities. Results In group 2 the development and severity of atherosclerosis was more in group 2 (see table 2 on the picture). We determined the hemodynamic main parameters increase in first post-extrasystolic contraction with the following tendency: if earlier extrasystole appeared in cardiocycle, than more changes were observed. Conclusion Extrasystoles are additional risk factors of atherosclerosis. Hemodynamic changes after the first post-extrasystolic contraction is the important mechanical trauma factor for the arterial vessels which can take part in atherosclerotic process. Weak places – carotid bifurcation, abdominal aorta bifurcation, large radius of aorta arch. We suppose that it’s necessary to treat the extrasystoles more than 3000 per 24 hours that appear early in cardiocycle (before the mitral valve opening and before the transmitral blood flow peak).