Abstract
Mesenchymal chondrosarcoma is an uncommon malignant mesenchymal tumor with an aggressive behavior. Diagnoses of mesenchymal chondrosarcoma are established based on histomorphological, immunohistochemical, and molecular findings. Only one case of extraskeletal mesenchymal chondrosarcoma (EMC) of the uterus has been reported. This article presents the second case of primary uterine EMC, occurring in a 33-year-old woman. We describe the histological and immunophenotypical features of EMC. Our observations will help pathologists and clinicians perform accurate histological diagnoses of uterine EMC and plan appropriate treatment strategies for this rare tumor.
Highlights
The diagnosis of Mesenchymal chondrosarcoma (MC) is established on the basis of histomorphology, in combination with immunohistochemical and molecular findings
The female genital tract is a rare site of origin for extraskeletal mesenchymal chondrosarcoma (EMC)
This report presents the second case of primary uterine EMC, occurring in a 33-year-old woman, and describes the clinical, histological, immunophenotypical, and molecular features of uterine EMC
Summary
Our literature seaBrccl-h2 reveale12d4 18 casDesakoof(Augtielernint Teecchhnoonlodgireos,sSaarnctaoCmlaara, ,wCAit,hUsSoAm) e of 1th:2e00m showing both mesencChDy1m0 al and56Cca rtilaNgoinvoocuasstrcao(LmeipcaoBnioesnysttsem[1s,0B]u. fHfaloo wGreovvee,rI,Lb, UaSsAe)d on1t:h10e0ir described clinical andChDis3t4ologQicBaElnfde-1a0turesD,awkoe(AcglailsenstifiTeecdhn1o7loogifest,hSean1ta8Cclaarsae,sCAas, UeSitAh)er pri1m:4a00ry. FHfaloo wGreovvee,rI,Lb, UaSsAe)d on1t:h10e0ir described clinical andChDis3t4ologQicBaElnfde-1a0turesD,awkoe(AcglailsenstifiTeecdhn1o7loogifest,hSean1ta8Cclaarsae,sCAas, UeSitAh)er pri1m:4a00ry. 1:50 chondrosarcomas, caPracni-nCoKsarcAoEm1/AasE, or mDyakxoo(iAdgiclehnot Tnedchrnoosloagriceso,mSanatsa.CFlairnaa, CllAy,,UwSAe)conclu1:d50e0d that uterine EMC reCpycolirnteDd1 byP2SDu11zFu11ki eNtovaolc.a[s1tr0a](LiesictahBeiosoynstleymsc,aBsueffaslho Gowrovien,gIL,hUiSsAto) logic1:5fe0 atures compatible witDhesmEMin C, coDn3fi rmedDbaykot(hAegilmentoTleecchunloalorgitees,sSta.ntTaaCblalrea,2CAs,uUmSAm) arize1s:2t0h0 e clinicopathological chaERracterist6iFc1s1of twNoovuoctaesrtrian(eLeEicMa BCiosycsatesmess,,BwufhfailcohGrsohvea,rILe, sUiSmA)ilar g1r:3o0s0s, PR. MIB1 Novocastra (Leica Biosystems, Buffalo Grove, IL, USA) 1:1200 histological, and genetic features. The clinical course of MC is frequently protracted and relentless, requiring a long-term follow-up. Some MC patients have developed distant metastases even after 20 years [2–4]. In the only previous case of uterine EMC [10], the patient experienced distant metastasis 52 months after surgery. A longer follow-up period would have been better for comparison and specification of the clinical course of uterine EMC. Our study could provide valuable information on the clinicopathological and genetic features of uterine. EMC, and help pathologists to not misdiagnose this rare sarcoma as other tumors
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