Abstract
Bone Biology Heterotopic ossification (HO) is the formation of ectopic bone in soft tissues at sites of injury-induced inflammation. Working in mice, Mundy et al. found that inflammatory cells and skeletal progenitor cells initially recruited to sites of HO formation expressed the gene Inhba , which encodes the TGF-β superfamily member activin A. Treating mice with an activin A–neutralizing antibody inhibited HO formation. These results suggest that interfering with activin A signaling may be effective in patients with HO. Sci. Signal. 14 , eabd0536 (2021).
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