Extraintestinal Seeding of Salmonella enterica Serotype Typhi, Pakistan.

Seema Irfan,Rumina Hasan,Sadia Shakoor,Mohammad Zeeshan,Salima Rattani,Afia Zafar,Joveria Farooqi

doi:10.3201/eid2703.200464

Abstract

We evaluated Salmonella enterica serotype Typhi strains isolated from all body sites in Pakistan during 2013–2018. Despite an increase in overall number of localized, extensively drug-resistant Salmonella Typhi in organ infections during 2018, there was no increase in the proportion of such isolates in comparison with non–extensively drug-resistant isolates.

Highlights

We evaluated Salmonella enterica serotype Typhi strains isolated from all body sites in Pakistan during 2013–2018
During the 6-year study period, 8,736 isolates of Salmonella Typhi were reported from blood, bone marrow, stool, and urine, and 62 isolates were reported from other body sites (Table 1)
Our study was a comparison of isolation rates of XDR and non-XDR Salmonella Typhi from extraintestinal organ infections after the recognition of an XDR Salmonella Typhi outbreak in Pakistan

Summary

Introduction

We evaluated Salmonella enterica serotype Typhi strains isolated from all body sites in Pakistan during 2013–2018. Seeding of deep-seated organs by Salmonella Typhi, resulting in bone and soft tissue infections and splenic and hepatic abscesses, has been reported (6–9). During 2018, a sudden increase in isolation frequency of XDR Salmonella Typhi from clinical samples other than blood, stool, and urine in Pakistan was observed.

Results

Conclusion