Abstract
IT is generally assumed that only small amounts of ethanol are metabolized outside the liver in man1,2. The results obtained when working at very low concentrations of ethanol, where the metabolic capacity of the liver is no longer fully saturated, are not consistent with this view. When the concentration of ethanol in the blood reaching the liver is below 50–60 mgm./l., the concentration in the liver vein, obtained by catheterization, has been found to be zero. If extrahepatic metabolism can be excluded the amount metabolized at these levels of ethanol must be proportional to the liver blood flow and to the concentration in the blood. Measurements of the liver blood flow by means of ethanol and bromsulphalein have shown, that the blood flow during experiments at periods similar to those mentioned below, is almost constant3,4. The amounts of ethanol metabolized can therefore be proportional only to the concentration in the blood.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
