Abstract
Chronic serum sickness was produced in rabbits by intravenous injections of bovine serum albumin. Rabbits making a hyperactive antibody response to multiple injections each day of high doses of bovine serum albumin developed glomerulonephritis and extra-glomerular lesions characterized by accumulation of inflammatory cells in the interstitium, in Bowman's capsule, in the walls of peritubular capillaries and by tubular atrophy and interstitial fibrosis. Granular deposits of bovine serum albumin, rabbit IgG, IgM and C3 were seen by immunofluorescence microscopy in these structures, corresponding to electron-opaque deposits observed by electron microscopy. The deposits presumably contained antigen-antibody complexes. Extra-glomerular renal changes were not reported in previous studies of experimental serum sickness in rabbits. Therefore it is likely that the different system of immunization used in these experiments may produce formation of larger amount of immune complexes and/or longer persistence of critical levels of complexes in the circulation than in rabbits receiving daily a single injection of bovine serum albumin. The lesions described in this paper are comparable to those observed in the kidneys of patients with active systemic lupus erythematosus glomerulonephritis.
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