Abstract
AbstractThe aim of this report is to describe an unusual localization of nerve sheath tumour (NST), clinical presentation, imaging, surgical management, and outcome in a 2-year-old dog. A 2-year-old female American Staffordshire Terrier presented with nonambulatory paraparesis, thoracolumbar hyperaesthesia, hindlimb hyperreflexia, and mild muscle atrophy. Computed tomography and magnetic resonance imaging revealed an extradural mass at T7-T8, without vertebral lesions. Surgical treatment consisted in resection of the soft tissue mass through dorsal laminectomy. The dog was ambulatory within 24 hours and free of recurrence at 18 months postoperatively. Histopathologic and features of immunohistochemistry were consistent with NST. The NST of this report was similar to those described before, but exhibited unusual characteristics, such as being extradural, without extension into intervertebral foramina, and being located in an atypical region (T7-T8). Moreover, survival time and relapse-free interval are greater than previously reported for similar cases.
Highlights
Intraspinal neoplasms can involve the spinal cord, dura mater, spinal nerves, or paraspinal tissues, resulting in clinical signs of spinal dysfunction
The Peripheral nerve sheath tumours (PNSTs) are a heterogeneous group of neoplasms that may originate from Schwann cells or related cells of the perineural sheath or from a combination of endoneurial, epineurial, or stromal fibroblasts.[3,7]
Peripheral nerve sheath tumours develop mainly from peripheral nerves, but they may extend along the nerve roots through the intervertebral foramen developing an EM component or may even involve the spinal cord’s grey matter.[3,19,20]
Summary
Intraspinal neoplasms can involve the spinal cord, dura mater, spinal nerves, or paraspinal tissues, resulting in clinical signs of spinal dysfunction. According to their location relative to spinal cord and dura mater, they are classified as intramedullary (IM), intradural-extramedullary (ID-EM), or extradural (ED).[1,2] The ED tumours have been described to account for 50% of all spinal cord neoplasms in dogs, followed by ID-EM reported with an overall distribution of 35%; IM tumours are least common, comprising the remaining 15%.2. We report a PNST in a 2-year-old dog, extradurally at T7, which is an infrequent location,[1,3,5] and the successful long-term outcome after surgical excision
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