Abstract
Descurainia sophia is widely distributed in China and is one of the most troublesome annual weeds. It has diverse medicinal usage. D. sophia has abundant oil, making it an important oil plant in China. The main goal of this study was to obtain the maximum yield of the oil by an optimal selection of supercritical fluid extraction parameters. According to the central composite design and response surface methodology for supercritical fluid extraction method, a quadratic polynomial model was used to predict the yield of D. sophia seed oil. A series of runs was performed to assess the optimal extraction conditions. The results indicated that the extraction pressure had the greatest impact on oil yield within the range of the operating conditions studied. A total of approximately 67 compounds were separated in D. sophia seed oil by GC-MS, of which 51 compounds represented 98.21% of the total oils, for the first time. This study was also aimed at evaluating the anti-asthmatic, anti-tussive and expectorant activities in vivo of D. sophia seed oil which supplied for further research on bioactive constituents and pharmacological mechanisms.
Highlights
Oil seeds of plants are usually extracted with organic solvents intended to remove the neutral lipids.In routine laboratory extraction methods, oil extraction requires a long time to complete and consumes significant amounts of solvents
There were a total of 20 runs for optimizing the three individual parameters in the current central composite design (CCD)
The results showed that positive and D. sophia seed oil could enhance tracheal phenol red output, compared with that of control
Summary
Oil seeds of plants are usually extracted with organic solvents intended to remove the neutral lipids.In routine laboratory extraction methods, oil extraction requires a long time to complete and consumes significant amounts of solvents. Oil seeds of plants are usually extracted with organic solvents intended to remove the neutral lipids. For technological, economical and environmental safety issues, research is currently geared towards the development of alternative extraction procedures using environmentally-friendly technologies as well as other organic solvents [1,2,3]. Common gases, such as carbon dioxide (CO2), in their supercritical state have properties and extraction capacities very similar to liquids [4]. Selection of the extraction conditions (pressure, temperature and time) can affect the final yield [6,7,8]
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