Abstract
For the laser treatment of vascular dermatosis, the blood vessel morphology and depth in skin tissue is essential to achieve personalized intelligent therapy. The morphology can be obtained from the laser speckle imaging, and vessel depth was extracted by an inverse methodology based on diffuse reflectance spectrum. With optimized spot size of 0.5 mm and known optical properties, the proposed method was experimentally validated via the spectral measurement of microcapillary with known size and depth embedded in an epoxy resin-based skin phantom. Results prove that vessel depth can be extracted with an average relative error of 5%, thereby providing the foundation for a personalized, precise, and intelligent laser treatment of vascular dermatosis.
Highlights
As a typical congenital vascular dermatosis, port wine stain (PWS) birthmarks can negatively affect the physical and mental well-being of individuals because 90% of these marks appear on the face and neck [1]
Comparing the calculated blood vessel depth with the known depth, 36 error in calculating the spectrum comes from the inversion error is less than 5%
The model was experimentally validated by constructing a skin phantom and conducting spectral measurements, which demonstrated consistency between the measured and calculated spectroscopic data
Summary
As a typical congenital vascular dermatosis, port wine stain (PWS) birthmarks can negatively affect the physical and mental well-being of individuals because 90% of these marks appear on the face and neck [1]. PWS has been demonstrated to be curable via lasermediated therapies based on selective photothermolysis [2]. The therapeutic effect of the laser on PWS is still far from satisfactory due to the complexity of the malformed capillaries [3], and the cure rate has remained below 20% for nearly 10 years via pulsed dye laser (585/595 nm) [4]. Multipulse Nd:YAG laser (1064 nm) has demonstrated a preferable potential even for resistant PWS [5]. The selection of laser parameters (e.g., frequency, fluence, and pulse number) lacks quantitative guidance. Similar problems exist in most types of vascular dermatosis primarily due to experiencedependent treatments
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