Abstract
Resveratrol is thought to have many benefits to human health, including anti-oxidant and anti-cancer properties. It can be found in grapes and peanuts, but at low concentrations, and extraction from these sources involves enormous waste. A highly invasive and low-value plant, polygonum cuspidatum (PC) is a good source of resveratrol, provided an efficient method of extraction is developed. We report on the development of magnetic molecularly imprinted polymer particles that bind resveratrol, which could be used for the extraction of resveratrol from PC extracts. Magnetic nanoparticles were included in the synthesis to allow magnetic separations. Rather than using resveratrol itself as the imprinting template, a less expensive compound sharing important functional groups (orcinol) was used. The target recognition ability of the magnetic orcinol-imprinted poly(ethylene-co-vinyl alcohol) composite particles, MOIPs, was examined. Finally, in vitro suppression of human osteogenic sarcoma (HOS) cells by MOIPs, with and without resveratrol, was studied. Delivery of resveratrol via the imprinted polymer particles substantially increased the toxicity to these tumor cells.
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