Abstract
Extraction of Quercetin from Nothopanax scutellarium Leaves via Ionic Liquid-based Microwave-assisted Extraction
Highlights
Nothopanax scutellarium leaves have been used in Indonesian traditional medicine to treat several diseases
Extraction with 1-butyl-3-methylimidazolium chloride using NaCl as the separation salt was associated with the highest total flavonoid (360.57 mg/g) content among the ionic liquid (IL), whereas 1-butyl-3-methylimidazolium tetrafluoroborate combined with sodium chloride generated the highest quercetin content (26.13 mg/g)
1-butyl-3-methylimidazolium tetrafluoroborate is the optimal solvent for extracting quercetin from N. scutellarium leaves
Summary
Nothopanax scutellarium leaves have been used in Indonesian traditional medicine to treat several diseases. Previous studies used conventional extraction methods with large volumes of organic solvents, long extraction times, and low levels of quercetin content. Quercetin is a major flavonoid in most plant extracts.[5] Quercetin is known for anti-oxidant, anti-inflammatory, anti-obesity, anti-hypertensive, vasodilatory, anti-hypercholesterolemic, antiatherosclerotic, anti-bacterial, and anti-biofilm effects.[6,7,8,9] the conventional method for extracting this flavonoid uses large volumes of organic solvent. This process is limited by long extraction times and low active compound levels. In ethanol extracts of mangkokan Leaf an average at 1.53%, in ethyl fractions acetate an average at 4.79%, and ethyl acetate extract at 1.64%, ethyl acetate fraction at 5.83%.2-3
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