Abstract
The extraction and separation conditions of glycyrrhizic acid and glabridin from licorice were investigated. By changing the different extraction solvents, procedures, times and temperature, the optimum extraction condition was established: the used of ethanol/water (30:70, v/v) as an extraction solvent, and 60 min dipping time under 50 degrees C. The extracts of licorice were separated and determined by reversed-phase high performance liquid chromatography with a methanol/water (70:30, v/v, containing 1% acetic acid) as the mobile phase. Under the optimum extraction condition, 2.39 mg/g of glycyrrhizic acid and 0.92 mg/g of glabridin were extracted from Chinese licorice and the recoveries were 89.7% and 72.5% respectively.
Highlights
Licorice, the root of the glycyrrhiza plant species, has been used medicinally for more than 4000 years [1]
The different extraction solvents used in the experiment for the extraction of glycyrrhizic acid (GA) and glabridin from licorice were water, methanol, ethanol, acetonitrile and chloroform. 50 mLs of each solvent was used to extract 1.0 g licorice for 240 min under room temperature respectively
Water and ethanol were obtained as the extraction solvent for the following experiment
Summary
The root of the glycyrrhiza plant species, has been used medicinally for more than 4000 years [1]. The genus glycyrrhiza consists of approximately 30 species, in which six species produce a sweet saponin glycyrrhizic acid (GA), and they are widely used in Asia countries [2]. These medicinal plants were used as flavorings, sweeteners and as herbal medicine, and they were used for improving health, detoxification and cures for injury [3].
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