Abstract
The results of a study of the extraction of ergot alkaloids from the crude drug by tetrahydrofuran, tetrahydrofuran-water azeotrope (4.3 per cent water), and tetrahydrofuran-water solution (50 per cent v/v) is presented. The preparation of a tetrahydrofuran-chloroform azeotrope is reported and its composition determined by index of refraction measurements. This azeotrope yielded the highest degree of alkaloidal extraction of any of the tetrahydrofuran mixtures employed. The selectivity of these solvent mixtures for color principles and emulsion-forming constituents of the crude drug is also discussed. All original extractions were carried out in the absence of alkalinity. Thus the ability of the solvents to extract the alkaloids as they occur naturally could be determined.
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