Extraction of Ecdysterone-80 from Serratula coronata L. and evaluation of its pharmacological actions. II. Cardioprotective properties. Effects on hormone- transmitter balance in chronic cardiac failure

Abstract

Experiments on animals (white rats) showed that “Ecdysterone-80” has a beneficial neurohormonal profile in experimental chronic cardiac failure (CCF), decreasing and in terms of some measures eliminating the hormone-transmitter imbalances characteristic of CCF. In addition, the study compound significantly decreased lethality among the animals and prevented the development of myocardial hypertrophy. These results may be of value for scientific investigations and for the introduction of production technology for a new pharmaceutical agent containing ecdysteroids from S. coronata with marked adaptogenic, gastroprotective, and antihypoxic actions (see communication I), along with cardioprotective properties.