Abstract
In this study, shells of sea crab and fungus Aspergillus niger were subjected for chitosan extraction which has been done following demineralization, deproteination and deacetylation. Chitosan yield from crab shell and fungi was 37.5% and 39.3% respectively and water binding capacity was 58.44% and 60.21% respectively. The extracted chitosan was characterized using Fourier transform infrared spectroscopy (FTIR) and subjected for antibacterial activity against Urinary tract infection (UTI) pathogens – Klebsiella pneumoniae, Proteus mirabilis and E. coli. Chitosan of crab shell showed better antibacterial activity than fungal derived chitosan. Chitosan gel was prepared using the extracted chitosan where it was also showing good antibacterial activity.
Highlights
Chitin, an abundant natural amino polysaccharide which is a constituent of exoskeleton of shrimp, crab etc and seen on fungi cell walls[1,2]
Its non-toxicity and non-allergenicity made them to be used in biomedical applications and used in treating wounds9- . 12,4 Chitosan coated nanoparticles are used for heavy metal removal, nanocarrier synthesis, drug delivery etc[13,14,15,16,17,18]
If derived from biological sources it might be having less side effect[22], chitosan is one such which can be derived from crab shell and fungal cell wall
Summary
An abundant natural amino polysaccharide which is a constituent of exoskeleton of shrimp, crab etc and seen on fungi cell walls[1,2]. Deacetylated form of chitin is chitosan which consists of polymer of N-acetyl D-glucosamine bonded through β-1,4glycosidic bond[3,4]. This chitosan has multiple functional properties and biological activities used in pharmaceutical, nanotechnology and agricultural industries 5- 8. Urinary tract infections (UTI), commonly caused by bacteria and their pathogenicity depends on host biological behavioral factors and properties of the infecting uropathogens[19]. If derived from biological sources it might be having less side effect[22], chitosan is one such which can be derived from crab shell and fungal cell wall. In this study, chitosan of crab shells and fungal cell walls was extracted and used for antibacterial activity against UTI pathogens
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