Abstract
Guava is considered as poor man’s apple rich in phytochemicals with medicinal value and hence it is highly consumed. Gas chromatography–mass spectroscopy (GC–MS) analysis of guava leaf extract revealed the presence of various bioactive compounds with antimicrobial, antioxidant, anticancer, and antitumor properties. Hence, it is used in tooth paste formulations along with other ingredients such as Acacia arabica gum powder, stevia herb powder, sea salt, extra virgin coconut oil, peppermint oil in the present study. Three formulations F1, F2 and F3 have been made by varying the concentration of these ingredients and the prepared formulations were studied for their antimicrobial activity and physico-chemical parameters such as pH, abrasiveness, foaming activity, spreading and cleaning ability. Among these, F3 showed significant antioxidant and antimicrobial properties, minimal cytotoxicity, maximum spreadability and very high cleaning ability. This study surmises that the herbal toothpaste formulation is greener, rich in medicinal values and imparts oral hygiene.
Highlights
Psidium guajava (Guava) is an evergreen tree that belongs to the family Myrtaceae, grows in tropical and subtropical regions but preferably in dry climates
Extraction of guava leaf extract and identification of bioactive compounds In the present study, the extraction of bioactive compounds from the guava leaf was carried out using ethyl acetate
The ethyl acetate extract was subjected to Gas chromatography–mass spectroscopy (GC–MS) analysis which has manifested the presence of sesquiterpenes and fatty acids predominantly (Fig. 1, Table 2)
Summary
Psidium guajava (Guava) is an evergreen tree that belongs to the family Myrtaceae, grows in tropical and subtropical regions but preferably in dry climates. It is originated from Mexico or Central America and due to its health benefits it is grown abundantly in various countries that include Brazil, Bangladesh, China, Indonesia, India, Nigeria, Mexico, Pakistan, Thailand and Philippines (Uzzaman et al 2018). It is commercially cultivated in almost all the states of India. To impart the beneficial aspects of the guava leaf extract to the daily used products, an attempt was made to formulate a tooth paste with guava leaf extract as a major ingredient in the present work
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