Abstract
Zymogen granule is an enzymatic vesicle in the pancreas. The surface of the zymogen granules (ZGs) has several different kinds of myosin molecules, such as myosin Ib, VI, VIIb, and Vc. These molecular motors may contribute ZG's transportation in cells. To understand the molecular motors involved in the vesicle trafficking, we observed the in vitro motility of the purified ZGs from rat pancreas and exam the stepping manner and force that is used by a single beam optical tweezer. The average speed of the ZGs is around 100 nm/sec, which is similar to our previous study that two myosin Vc molecules tagged with the DNA origami.
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