Abstract
The feasibility of cascade process for penicillin G recovery utilizing hollow fiber renewal liquid membrane (HFRLM) technique was investigated and the optimal conditions were determined. Cascade process of HFRLM was carried out to recover penicillin G from the aqueous solution using di-n-octylamine in iso-octanol and kerosene as the liquid membrane phase and K2CO3 aqueous solution as the stripping phase. The mass transfer performance of the process was evaluated in a hollow fiber module with 1000 microporous and hydrophobic polypropylene (PP) hollow fibers. The cascade process of HFRLM was feasible for penicillin G recovery and the enrichment factor, extraction and recovery efficiency were larger than that of single-stage process. The stripping phase of 0.5molL−1K2CO3 solution could not only keep the efficiency of re-extraction, but also ensure the stability of penicillin G. Besides, the results indicated that 0.2molL−1 potassium dihydrogen phosphate solution as the buffer solution in the feed solution could greatly reduce the loss of penicillin G due to the pH fluctuation. In the cascade mode operated at the flow rates of 45mLmin−1 in the shell side and 20 mLmin−1 in the tube side, the extraction and recovery efficiency of 97% and 82% for penicillin G were achieved after 7 stages respectively. The cascade process of HFRLM for penicillin G recovery exhibits good potential in industrial application.
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