Abstract

The work proposes a computer-based diagnosis method (CBDM) to delineate and assess the corpus callosum (CC) segment from the 2-dimensional (2D) brain magnetic resonance images (MRI). The proposed CBDM consists of two parts: (1) preprocessing and (2) postprocessing sections. The preprocessing tools have a multithreshold technique with the chaotic cuckoo search (CCS) algorithm and a preferred threshold procedure. The postprocessing employs a delineation process for extracting the CC section. The proposed CBDM finally extracts the vital CC parameters, such as total brain area (TBA) and CC area (CCA) to classify the considered 2D MRI slices into the control and autism spectrum disorder (ASD) groups. This attempt considers the benchmark brain MRI database which includes ABIDE and MIDAS for the experimental investigation. The results obtained with ABIDE dataset are further confirmed against the fuzzy C-means driven level set (FCM + LS) and multiphase level set (MLS) technique and the proposed CBDM with Shannon entropy along with active contour (SE + AC) presented improved result in comparison to the existing methodologies. Further, the performance of CBDM is confirmed on MIDAS and clinical dataset. The experimental outcomes approve that the proposed CBDM extracts the CC section from the 2D MR brain images that have higher accuracy compared to alternative techniques.

Highlights

  • Corpus callosum (CC) is one among the vital brain parts responsible for neural communication among the two brain sections

  • This work deliberates standard brain magnetic resonance images (MRI) dataset identified as ABIDE, in which test images are associated with ground truth (GT)

  • The mathematical terminologies are presented in Eqs. (15)–(18): JaccardðIG, ICÞ = IG ∩ ICIG ∪ IC, ð15Þ

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Summary

Introduction

Corpus callosum (CC) is one among the vital brain parts responsible for neural communication among the two brain sections. The work by Hinkley et al (2012) on agenesis of corpus callosum (ACC) confirms that CC plays a significant role in problem cracking schemes and swiftness in vocal processing [2]. The study of Paul et al (2014) presents the relation of ACC and autism [3]. Their work confirms that the CC disorder will lead to autism. Many works are reported to observe autism disorder based on CC [4,5,6,7]. Some of similar research works report the study of sexual dimorphism in CC [8,9,10,11,12,13,14]

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