Abstract
Despite considerable global surveillance of antimicrobial resistance (AMR), data on the global emergence of new resistance genotypes in bacteria has not been systematically compiled. We conducted a study of English-language scientific literature (2006-2017) and disease surveillance reports (1994-2017) to identify global events of novel AMR emergence (first clinical reports of unique drug-bacteria resistance combinations). We screened 24,966 abstracts and reports, ultimately identifying 1,773 novel AMR emergence events from 294 articles. Events were reported in 66 countries, with most events in the United States (152), India (129), and China (128). The most common bacteria demonstrating new resistance were Klebsiella pneumoniae (352) and Escherichia coli (218). Resistance was most common against antibiotic drugs imipenem (89 events), ciprofloxacin (85) and ceftazidime (82). We provide an open-access database of emergence events with standardized fields for bacterial species, drugs, location, and date, and we discuss guidelines and caveats for data analysis. This database may be broadly useful for understanding rates and patterns of AMR evolution, identifying global drivers and correlates, and targeting surveillance and interventions.
Highlights
Antimicrobial resistance (AMR) is a global health crisis that has compromised the effective treatment and prevention of a multitude of infections
In 2014, the World Health Organization (WHO) published surveillance data obtained from 129 member states on nine bacterial pathogen-antibacterial drug combinations of public health importance, finding high rates of resistance reported across the globe[3]
We focused on human clinical cases and included any reported resistance of a bacterium to an antimicrobial drug
Summary
Standardized fields for bacterial species, drugs, location, and date, and we discuss guidelines and caveats for data analysis. This database may be broadly useful for understanding rates and patterns of AMR evolution, identifying global drivers and correlates, and targeting surveillance and interventions. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
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