Abstract
The present paper discusses the clinical application and scientific evidence of the special Extract Rheum rhaponticum (ERr) 731, derived from the roots of the rhapontic rhubarb. Originally used to treat irregular menstrual cycles, ERr 731 is now primarily employed to alleviate menopausal symptoms. The extract has a similar mode of action to estrogens, has been found to be a highly selective ERβ agonist, and showed to be clinically safe and effective. Studies suggest that ERr 731 can reduce anxiety, depressed mental state, sleeping disorders, and hot flushes more effectively than low-dose hormone therapy. Furthermore, unlike certain synthetic hormones, ERr 731 is not listed as an endocrine disrupting chemical and may serve as a more environmentally friendly alternative. It has advantages in terms of crop yield, resistance against pests and diseases, and reliable production. Overall, ERr 731 may offer significant benefits for patients and manufacturers.
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