Abstract
Solidago chilensis Meyen (= Solidago microglossa) popularly known as “Brazilian arnica” is used to treat of inflammatory disorders. S. chilensis is constant in the Therapeutic Memento of the Rio de Janeiro city and belongs to the medicinal species of Brazilian National List of Medicinal Plants of Interest of the Unified National Health System (SUS). There are no studies in the literature showing the direct activity of this plant species on immune system cells. The present study evaluated the chemical composition as well as the cytotoxic and pharmacological activity of the ether-ethanol extract from S. chilensis inflorescences (SCIE) in murine macrophage cell line J774A.1. The results showed that higher concentrations (50 to 200 µg/mL) of SCIE had significant cytotoxicity on J774A.1 cells, however, lower concentrations (from 10 to 0.1 µg/mL) did not produce significant cytotoxic effects and exhibited an inhibitory effect on nitric oxide production in LPS-stimulated J774A.1 cell line. The chemical analysis by HPLC-UV-PDA indicated that the SCIE contains flavonoid derived from quercetin and kaempferol; and diterpenes, probably labdanes. These findings complement data in the literature regarding the activity of this plant species on an important cell from the immune system involved in the innate and acquired immune response, the macrophages.
Highlights
Solidago chilensis Meyen is a member of the Asteraceae family widely used in Brazilian folk medicine, as well as in other countries of North and South America
To investigate the effect of S. chilensis on macrophage activation, we evaluated the ability of S. chilensis inflorescences (SCIE) to modulate the nitric oxide (NO) production on LPS-stimulated J774A.1 macrophages
The results present in this study suggest that the SCIE is potentially toxic to macrophages
Summary
Solidago chilensis Meyen is a member of the Asteraceae family widely used in Brazilian folk medicine, as well as in other countries of North and South America. This plant species is part of the Brazilian. Macrophages are highly versatile immune cells that play a key role in the innate immune response system. They form a bridge between innate and acquired immune response systems. We evaluated the in vitro toxicity of the ether-ethanol extract from S. chilensis inflorescences (SCIE) on a cell lineage of murine macrophages. A chemical analysis was performed to determine the phytochemical constituents of the SCIE
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