Abstract
Nanas Bongsai (Ananas comosus var. microstachys L.) is an amazing herb which is used in traditional medicine by local people of Muara Lembu district as a potion to reduce pain while menstruation period for a women. The present work was designed to investigate its probable side effects on the histopathologic changes in limph and uterus tissues after treated with A. comosus var. microstachys L extract in female white rats. This is an experimental research consisted of five treatments and three repetitions. Treatment composed of two controls (P0 and P+) and given Nanas Bongsai extract with three different dosages. Histology result of lymph show that all treatments given with Nanas Bongsai with three different dosages have different diameter average of white pulp and there is no significant changes with normal control. While observation towards histology structure of endometrium thickness with dosage P1, dosage P2, dosage P3 is 206.333±33.486; 215.667±33.486; 197.667±60.871 respectively. The most thin endometrium layer found in treatment with dosage P3 compared to control P0. From this study showed that there is no toxic effect on uterus and lymph function of of Nanas Bonsai (A. comosus var. microstachys L.) at different doses, so the plant is secure for consumption by the community.
Highlights
Utilization of medicinal plants has long been kwon by Indonesians called as jamu
From this study showed that there is no toxic effect on uterus and lymph function of of Nanas Bonsai (Ananas comosus var. microstachys L.) at different doses, so the plant is secure for consumption by the community and will not cause toxicity effect on the limph and uterus function
Based on data analysis there is no significant effect towards endometrium layer as well as myometrium
Summary
Utilization of medicinal plants has long been kwon by Indonesians called as jamu. Knowledge about utilization this medicine has inherited from generation to generation both oral and lettering. Utilization of this medicine have widely used by local people. One noticeable reason to use this plant is high price of synthetic medicine (Cottencin et al, 2014). According to World Conservation Monitoring Center claimed that Indonesia was a region that rich of many medicinal plant. Medicinal plant that has been utilized about 2.518 kind of medicinal plant (EISAI, 1995). In Indonesia at least 3000 kinds of medicinal plant have been identified (Zuhud & Hikmat, 1998). Knowledge of herbal medicine and mixed herbal potions originally came from the knowledge of local community gained inadvertently as indigenous knowledge and developed by generations (Fitmawati et al 2017)
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