Extracranial Metastasis of Glioblastoma: A Case Report

Abstract

Glioblastoma is the most frequent malignant neoplastic pathology among glial neoplasms, extra neural metastases are atypical, presenting in 0.2 to 2% of cases, risk factors include recurrence of the neoplasm, early age of the patient, and prolonged survival. The most frequent localization sites of metastases are lungs, cervical lymph nodes, bone tissue. This article details the case of a 36-year-old patient with no history of previous disease who presented tonic-clonic seizures. In extension tests, a right frontal intracranial tumor was observed. It was decided to perform resection of the tumor with pathology results that indicated a grade IV right frontal glioblastoma, presents a recurrence of the disease, for which reason a surgical reintervention is warranted and subsequent treatment with radiotherapy and chemotherapy one year after the second surgery, a right temporal extracranial lesion is evidenced, which was biopsied and reported as glioblastoma with a component primitively, resection of the tumor mass was chosen with the double scalpel technique and reconstruction with a cervicofacial flap and skin graft. Late post-surgical patient with adequate pain control, without signs of inflammatory response, without evidence of neurological deficit, is discharged.