Extracorporeal Photophoresis in Reduced Intensity Conditioning: 14 Year Follow-up of 206 Patients Reveals an Efficacious Regimen with Low Rates of GVHD

Abstract

s / Biol Blood Marrow Transplant 21 (2015) S30eS53 S35 grade 3-4 aGVHD post PBSC alloHCT was 14% and 10% in the Caucasians and Japanese, respectively (Figure 1B). In multivariate analysis, the interaction term between race and graft source was not significant in any of the models, indicating that the impact of race on outcomes does not differ according to graft source. The risk of grade 3-4 aGVHD was significantly lower in Japanese compared to Caucasians (HR 0.74, 95% CI 0.57-0.96), which resulted in lower risk of non-relapse mortality (NRM) in Japanese compared to Caucasian patients (HR 0.69, 95% CI 0.54-0.89). The risk of relapse was also lower in Japanese compared to Caucasian patients (HR 0.75, 95% CI 0.63-0.89). Lower risk of NRM and relapse resulted in lower overall mortality rates in Japanese compared to Caucasians (HR 0.70, 95% CI 0.59-0.83). The risk of grade 3-4 aGVHD was significantly higher in PBSC compared to BM alloHCT recipients (HR 1.63, 95% CI 1.202.20), which resulted in higher NRM (HR 1.31, 95% CI 1.041.65) in PBSC compared to BM alloHCT recipients. Conclusions: Irrespective of graft source, the risk of severe aGVHDwas lower in Japanese patients, which resulted in the lower risk of NRM. The risk of severe aGVHD was higher in the PBSC alloHCT recipients, which resulted in the higher risk of NRM.