Abstract
Aim: To assess clinical efficacy of extra-corporeal photochemotherapy (EPCT) in the treatment of rare lymphomas – lymphomatoid papulosis and folliculotropic mycosis fungoides. Materials and methods: This is a presentation of two cases of lymphomatoid papulosis and folliculotropic mycosis fungoides treated with EPCT with duration of follow-up 9 and 12 years. Extracorporeal photochemotherapy involved administration of 8-methoxypsoralen 0.6 mg/kg 1.5–2 hours before the initiation of intermittent flow separation of mononuclear cells using Haemonetics MCS+ blood cells separator and corresponding protocol. Cell suspension was exposed to UVA-radiation (λ=320–400 nm) using blood irradiator Julia (10–15 ml/min) during 30 minutes then re-infused. In total, 4 procedures were conducted every other day. Results: Both patients demonstrated positive effect involving regression of the rashes after 3 EPCT cycles. Subsequently, the patients received maintenance EPCT 2–3 times a year. Conclusion: High clinical efficacy of EPCT was demonstrated in 2 patients with lymphomatoid papulosis and folliculotropic mycosis fungoides after 9 and 12 years of follow-up.
Highlights
Цель – оценить клиническую эффективность экстракорпоральной фотохимиотерапии (ЭФХТ) в лечении редких типов лимфом – лимфоматоидного папулеза и фолликулотропного варианта грибовидного микоза
This is a presentation of two cases of lymphomatoid papulosis
folliculotropic mycosis fungoides treated with EPCT with duration
Summary
Цель – оценить клиническую эффективность экстракорпоральной фотохимиотерапии (ЭФХТ) в лечении редких типов лимфом – лимфоматоидного папулеза и фолликулотропного варианта грибовидного микоза. Представлены 2 клинических случая лимфоматоидного папулеза и фолликулотропного варианта грибовидного микоза у пациентов, получавших лечение методом ЭФХТ. Положительный эффект в виде регресса высыпаний был получен у обоих больных после 3 курсов ЭФХТ. На примере 2 пациентов, наблюдавшихся в течение 9 и 12 лет, продемонстрирована высокая клиническая эффективность ЭФХТ в лечении лимфоматоидного папулеза и фолликулотропного варианта грибовидного микоза.
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