Abstract
CRITICAL evaluation of cerebral metabolism and intracranial fluid distribution necessitates complete isolation of the brain's blood supply; however, brain viability must be demonstrated and maintained for such studies to be meaningful. Most investigators1–3 have been unable to establish satisfactorily the viability or complete vascular isolation of the animal brain. Recently, White et al.4 described the isolation of the monkey brain by removal of all anatomical structures surrounding the brain except a small basal plate of bone and the central portion of the skull. In order to minimize handling of the brain substance, a factor which may disturb fluid distribution and cerebral metabolism, we have chosen to leave the brain within the skull during perfusion.
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