Abstract
Temperature regulation of magnetic thermotherapy used for the treatment of diseases needs to be precise and accurately controllable. Substantial efforts have been focused recently on manipulating the parameters of alternating magnetic field (AMF) and developing nanoparticles with low Curie temperatures for a desired thermotherapy temperature. Herein, a simple and effective approach for temperature control in magnetic thermotherapy through phase transition is reported. In general, extracorporeal magnetic thermotherapy materials are synthesized by introducing superparamagnetic nanoparticles in a phase change material with high phase transition enthalpy in the thermotherapy temperature range of 41 °C–47 °C. Given the magnetothermal effect of superparamagnetic nanoparticles and temperature control characteristics by phase transition of a phase change material, the temperature of the material in AMF can be self-regulated in the thermotherapy range. Moreover, the materials exhibit excellent thermal stability, form-stable properties, and outstanding reproducibility in temperature control for repeated use. This novel strategy may open a promising avenue for the study of temperature self-controlled thermotherapy.
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