Abstract
Background Myocardial extracellular volume fraction (Ve) measures from myocardial and blood pool T1 data quantify diffuse fibrosis (Flett, 2010) not detectable by conventional late gadolinium (Gd) enhancement, but require steady state equilibrium between plasma and interstitium. While a bolus with a lengthy infusion produces steady state for Ve measures, it is unclear whether a Gd contrast bolus alone (e.g., Broberg, 2010) is sufficient. Given the relatively slow clearance of Gd, we hypothesized that a simple bolus accurately measures Ve, thus facilitating integration of Ve measurement into CMR workflow routines.
Highlights
Extracellular volume fraction measured by modified Look Locker inversion recovery research sequence (MOLLI): slow infusion versus bolus
Myocardial extracellular volume fraction (Ve) measures from myocardial and blood pool T1 data quantify diffuse fibrosis (Flett, 2010) not detectable by conventional late gadolinium (Gd) enhancement, but require steady state equilibrium between plasma and interstitium
While a bolus with a lengthy infusion produces steady state for Ve measures, it is unclear whether a Gd contrast bolus alone (e.g., Broberg, 2010) is sufficient
Summary
Erik Schelbert1*, Stephen M Testa, Christopher G Meier, William J Ceyrolles, Joshua Levenson, Alex J Blair, Kathy S Puntil, Peter Kellman, Bobby L Jones, Daniel R Ludwig, Hua Zhong, David Schwartzman, Sanjeev G Shroff, Timothy C Wong. From 2011 SCMR/Euro CMR Joint Scientific Sessions Nice, France. From 2011 SCMR/Euro CMR Joint Scientific Sessions Nice, France. 3-6 February 2011
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