Extracellular Vesicles from Neural Stem Cells Transfer IFN-γ via Ifngr1 to Activate Stat1 Signaling in Target Cells

Abstract

(Molecular Cell 56, 193–204; October 23, 2014) The originally published Supplemental Information accompanying this article contained errors in Figures S5A–S5C. Figures S5A and S5B were labeled “Stat1−/− NIH 3T3” when they should have been labeled “Stat1−/− somatic fibroblasts.” In Figure S5C, the values on the y axis, referring to qPCR data on Stat1 expressed as 2−ΔCt over Gapdh, should have spanned from 0 to 8 × 10−2. These errors have since been corrected. Additionally, “nd” (not detectable) labels have been added to Figure S6A, and a number of small typos were corrected in the Supplemental Information text. The authors apologize for the inconvenience. Extracellular Vesicles from Neural Stem Cells Transfer IFN-γ via Ifngr1 to Activate Stat1 Signaling in Target CellsCossetti et al.Molecular CellSeptember 18, 2014In BriefUncovering cellular signaling events after stem cell transplantation is important to understand the full implications of stem cell therapy. Cossetti, Iraci et al. demonstrate that stem cells deliver functional IFN-γ to target cells via vesicle-associated Ifngr1, a mechanism that stem cells may use to communicate with the host immune system. Full-Text PDF Open Archive