Abstract
Background and Aims : Extracellular vesicles (EVs) are secreted into the extracellular space by several cell types. EVs carry proteins, lipids, and nucleic acids. EVs play a significant role in the process of atherosclerotic cardiovascular diseases (ASCVD). In the pathophysiology of ASCVD, proprotein convertase subtilisin/kexin type 9 (PCSK9) appears to play a crucial role, e.g., PCSK9 influences vascular smooth muscle cells (SMC) differentiation, migration and proliferation. Aim: To unveil the impact of EVs derived from human SMC overexpressing PCSK9 on the inflammatory milieu in in vitro (THP-1 and derived-macrophages) and in vivo (zebrafish) models.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
