Abstract
Background and Aims : Extracellular vesicles (EVs) are secreted into the extracellular space by several cell types. EVs carry proteins, lipids, and nucleic acids. EVs play a significant role in the process of atherosclerotic cardiovascular diseases (ASCVD). In the pathophysiology of ASCVD, proprotein convertase subtilisin/kexin type 9 (PCSK9) appears to play a crucial role, e.g., PCSK9 influences vascular smooth muscle cells (SMC) differentiation, migration and proliferation. Aim: To unveil the impact of EVs derived from human SMC overexpressing PCSK9 on the inflammatory milieu in in vitro (THP-1 and derived-macrophages) and in vivo (zebrafish) models.
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