Abstract
Cardiovascular diseases and cancer are the leading causes of mortality and morbidity in the world. The search for pertinent biomarkers for risk stratification and treatment monitoring is a challenge. Rapid advances in the identification of the molecular and functional content of extracellular vesicles (EV) and ongoing progress in developing highly sensitive methodologies, identify EV as promising biomarkers easily accessible in liquid biopsies. Thanks to robust and sensitive methodologies, the measurability of biological targets on EV allows to define vesicular biomarkers pertinent for disease management. Adaptation of the pre-analytical and analytical steps to each EV-associated biomarker, technological improvement and standardization efforts driven by scientific societies are essential prerequisites to accelerate the transfer of these EV-associated biomarkers to the clinics and to support the development of personalized medicine.
Highlights
Adaptation of the pre-analytical and analytical steps to each extracellular vesicles (EV)-associated biomarker, technological improvement and standardization efforts driven by scientific societies are essential prerequisites to accelerate the transfer of these EV-associated biomarkers to the clinics and to support the development of personalized medicine. ‡
Dejima H, Iinuma H, Kanaoka R, et al Exosomal microRNA in plasma as a non-invasive biomarker for the recurrence of non-small cell lung cancer
Summary
> Les maladies cardiovasculaires et les cancers sont les premières causes de mortalité et de morbidité dans le monde. Les progrès rapides faits sur l’identification du contenu moléculaire et fonctionnel des vésicules extracellulaires et le développement de méthodologies sensibles et robustes identifient ces dernières comme des biomarqueurs prometteurs, accessibles dans les biopsies liquides.
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