Abstract
inactivated serum was found to be due to IgG interacting via its Fc part with the Fc receptors in the surface of granulocytes and monocytes. Proof that such interactions occurred was provided by the following observations. Inbucation of phagocytes containing ingested bacteria in the presence of purified heterogeneous IgG, pFc fragments of IgG, or the subclasses IgGl and IgG3, for which membrane receptors are present on phagocytes, resulted in a decrease in the number of viable intracellular bacteria similar to that seen in the presence of heatinactivated serum. Incubation of phagocytes containing Staphylococcus aureus in the presence of IgM, (Fab')2 fragments of IgG, IgG2, or IgG4, for which no membrane receptors are present, gave a degree of killing not exceeding that observed with
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