Abstract
The extracellular matrix (ECM) plays an important role in cell migration and proliferation, and hence in the progression of malignant tumors. Healthy brain is one of the softest tissues, but in cancer, the stiffness of the brain ECM can increase by one or two orders of magnitude. Within the framework of studying mechanotransduction in brain tumors, we aim to construct a multiscale computational model of the brain ECM. In contrast to most tissues whose mechanical properties are governed primarily by collagen, the brain ECM is mainly composed of proteoglycans and hyaluronic acid. During cancer, expression of different proteoglycans is altered during remodeling of the brain ECM.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
