Abstract
Low-temperature atmospheric-pressure plasma (APP) jets and a metal stencil mask have been used for the patterning of fibronectins deposited on a silicon (Si) wafer. Fibronectins typically constitute the extracellular matrix (ECM) and a micro-patterned ECM may be used for arranging living cells in a desired pattern on the substrate surface. Such a technique can be used for the fabrication of cell chips. In this study, patterning of 100-µm-wide lines of fibronectin layers has been demonstrated. Desorption of fibronectins from the surface by plasma application has been confirmed by atomic force microscopy (AFM) and Fourier transform infrared spectroscopy (FT-IR).
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