Abstract
ABSTRACT Measurement of the volume of extracellular water (ECW) was performed simultaneously with determinations of glomerular filtration rate (GFR) and renal plasma flow (RPF) in 12 hypophysectomized patients (five cases of metastatic mammary carcinoma and seven diabetic subjects) and in 13 cases of acromegaly. Thirteen normal subjects served as controls. ECW was estimated from the volume of distribution of inulin, GFR and RPF from the renal clearances of inulin and para-aminohippurate, respectively. In the acromegalic group, an increased GFR and RPF was found together with an increased ECW, confirming earlier observations. In the hypophysectomized patients (who were all on cortisone replacement therapy), GFR and RPF were markedly decreased. However, the reduction in GFR and RPF was not associated with any significant changes in ECW.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
