Extracellular E-selectin levels and its association with insulin resistance: Putative role of E-selectin as a biomarker of oxidative stress linked vascular manifestations in diabetic nephropathy

Abstract

Introduction and aim: E-selectin, a cell adhesion molecule depicting nexus with oxidative stress in hyperglycemia has been documented in several other clinical conditions. The present study centers around the putative role of E-selectin as a biomarker of diabetic nephropathy linked to oxidative stress.
 
 Materials and Methods: 150 type 2 diabetics in the age group of 35 - 50 years were classified into three groups, comprising 50 each, based on albuminuria. Fifty healthy age and gender matched individuals constituted the control. Extracellular E-selectin and Insulin were quantitated appropriately. Measurement of HbA1c and microalbumin were also enabled. Routine biochemistry analyses were undertaken, based on established automated procedures. The study was initiated only following approval accorded by the Institutional Ethics Committee.
 
 Results: E-selectin levels in serum were significantly associated with Urine Albumin-to-Creatinine Ratio (UACR) and Insulin resistance in the light of estimated Glomerular Filtration Rate.
 
 Conclusion: E-selectin levels could thus act as a putative biomarker of diabetic nephropathy linked to oxidative stress, as observed in insulin resistant type 2 diabetes.