Abstract
Exocytosis of transmitter releasing vesicles is elicited by an elevation of intracellular Ca2+ concentration ([Ca2+]i). Given the existing Ca2+ sensor receptor (CaSR), although [Ca2+]i-induced exocytosis is fully established, however, whether extracellular Ca2+ (concentration [Ca2+]o) directly regulates exocytosis is not rigorously examined yet. Here we report that extracellular Ca2+ inhibited exocytosis following moderate [Ca2+]i rises (2-3 μM), which were triggered by either photolysis of caged Ca2+ or caffeine.
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