Abstract
The role of bicarbonate ions in insulin release was studied with incubated and perifused isolated rat islets of Langerhans. In the absence of NaHCO3, the early phase of glucose-induced secretion was completely abolished and the second phase inhibited by approximately 65%. The insulinotropic effect of the sugar was totally restored after reintroduction of the ion in the medium. The monophasic secretory response to tolbutamide was also markedly diminished by omission of NaHCO3, whereas the release evoked by a high concentration of K+ was very little affected. CO2 was unable to substitute for HCO3−, but small concentrations of the anion (3 to 5 mM) were sufficient to ensure a normal response to glucose.
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Schedule a callMore From: Biochimica et Biophysica Acta (BBA) - General Subjects
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