Abstract
The effects of ATP on the concentration of cytosolic calcium ([Ca 2+] i) were examined with respect to early events associated with activation of the superoxide ( O 2 −)- generating system in human neutrophils. Addition of ATP to cytochalasin B-treated neutrophils resulted in two sequential increase in [Ca 2+] i: an initial phase presumably related to the mobilization of Ca 2+ from intracellular stores and a second phase dependent upon the presence of extracellular Ca 2+. The second phase was associated with an increase in the rate of O 2 − production, which also required the presence of extracellular Ca 2+. The results suggest that increased Ca 2+ influx may act to trigger a cascade of Ca 2+-sensitive events, leading to stimulated O 2 − production.
Published Version
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