Abstract
BackgroundGranular cell tumor (GCT) is an uncommon benign tumor founded in any part of the body but mainly in the tongue. Extra-tongue oral granular cell tumor (ETOGCT) is rare with few cases reported. Here we describe seven cases of oral GCT located in sites other then the tongue and discuss histopathological and immunohistochemical differences between differential diagnoses.Material and MethodsWe retrieved all cases diagnosed with oral granular cell tumor, from the Oral Pathology Service at the School of Dentistry/ University of São Paulo, and excluded the ones sited in the tongue. Immunohistochemical staining anti-S100 was also performed.ResultsThe presented cases of Extra-tongue Oral Granular Cell Tumor (ETOGT) are composed by granular cells with intimately association with the adjacent tissue. Atypia and mitoses were not seen, and in most cases, the typical pseudoepitheliomatous hyperplasia was not observed.ConclusionsThe importance of an adequate attention is to avoid misdiagnoses, since ETOGT is rare and the tricking histopathological findings could induce to it. All the cases can be differentiated from the tumors that has a granular cell proliferation through a morphological analysis and when needed, immunohistochemistry stain. Key words:Abrikossoff`s tumor, granular cell tumor, oral cavity.
Highlights
Granular cell tumor is an uncommon benign neoplasm [1] that can be found in any part of the body but usually found in skin, respiratory tract, breast, gastrointestinal tract and over 50% in head and neck, mainly the tongue [2]
According to the World Health Organization (WHO), granular cell tumor is a benign tumor of soft tissue and is thought to be of Schwann cell origin [5]
Studies of its histogenetic origin have shown that all Oral Granular cell tumor (OGCT) are S-100 positive [12] and this protein is used as proteintarget for the diagnosis of this tumor
Summary
Granular cell tumor is an uncommon benign neoplasm [1] that can be found in any part of the body but usually found in skin, respiratory tract, breast, gastrointestinal tract and over 50% in head and neck, mainly the tongue [2]. Extra-tongue oral granular cell tumors are rare [3,4]. Establishment of OGCT diagnosis is easy but it can be misdiagnosed if not well observed, especially, because this lesion often shows a pseudoepitheliomatous hyperplasia, and islands of epithelium can be seen in the connective tissue [2,7]. Besides the pseudoepitheliomatous hyperplasia, this tumor is composed by polygonal cells with eosinophilic granular cytoplasm and small nuclei [4].
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
