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Abstract
Luteinizing hormone releasing hormone (LHRH) given intraventricularly caused a delayed, significant decrease of intraocular pressure (IOP) in adult female rabbits for a prolonged period, but only elevated plasma gonadotropins for a few hrs. Intravenous injections of LHRH caused a similar elevation of plasma gonadotropins without any effect on IOP. It indicates that LHRH initiates a mechanism in the central nervous system to decrease IOP, which is unrelated to the conventional LHRH-gonadotropin axis.
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