Abstract
Crohn's disease (CD) is an immune-mediated disorder of unknown etiology primarily affect the gastrointestinal tract with series of Extra intestinal manifestations (EIM) and Extra intestinal complications (EIC) that affects different organs and systems. In this review, we try to make stress on different previously reported frequencies of EIMs and EIC in patients with CD; from our point of view we make an overview on the ocular and pulmonary complications and manifestations that are related either to disease activity or an indication of the presence of CD. Sclerotis, uveitis and dry eye syndrome in previous healthy subjects with intestinal manifestation help in early diagnosis of CD especially in unexpected ages of the diseases. Further, work on pulmonary manifestations to make full explanation on whether pulmonary disease is secondary to the drugs or to the underlying disease process.
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