Extra-amniotic balloon with PGE 2 versus extra-ovular Foley catheter with PGF 2α in mid-trimester pregnancy termination

Abstract

Objective: The objective of this study was to compare the efficacy and side effects of two methods of mid-trimester labor induction, extra-amniotic balloon with intracervical prostaglandin (PG) E 2 (0.5 mg×2) vs. extra-ovular Foley catheter with intrauterine PGF 2α (1 mg/h ×6). Methods: A cohort of 32 and 36 cases indicated for mid-trimester termination was enrolled and managed with extra-amniotic balloon and extra-ovular Foley catheter methods, respectively. Outcomes of induction-to-delivery interval, induction failure, and occurrence of side effects were assessed. Results: There were no statistical differences in maternal age, parity, gestational age or fetal birth weight between the two groups. Compared with the extra-ovular Foley catheter with PGF 2α group, the induction-to-delivery interval was significantly shorter in the extra-amniotic balloon plus PGE 2 group. There was no significant difference in side effects and major complications developed in either groups. Conclusions: The extra-amniotic balloon with intracervical PGE 2 is more efficient in reducing the induction-to-delivery interval for termination of mid-trimester pregnancies than the extra-ovular Foley catheter with intrauterine PGF 2α.