Extinction of fear memory and cell proliferation in adult mouse hippocampus are increased by benfotiamine

Abstract

Event Abstract Back to Event Extinction of fear memory and cell proliferation in adult mouse hippocampus are increased by benfotiamine Julie Vignisse1, 2*, Nicolas Caron3, Natalia Markova4, Alexander Revishchin5, Pierre Wins1, Sergej Bachurin4, Harry W. Steinbusch2, 6, Tatyana Strekalova2, 6 and Lucien Bettendorff1, 2 1 University of Liege, GIGA-Neurosciences, Belgium 2 School for Mental Health and Neuroscience, Maastricht University, EURON - European Graduate School for Neuroscience, Netherlands 3 University of Liege, GIGA-Neurosciences, Belgium 4 Russian Academy of Sciences, Institute of Physiologically Active Compounds, Russia 5 Russian Academy of Sciences, Institute of Gene Biology, Russia 6 Maastricht University, Department of Translational Neuroscience, School for Mental Health and Neuroscience, Netherlands Because of the rising prevalence of Alzheimer’s disease (AD), new strategies to slow, halt and prevent the neurodegenerative process are urgently needed. Recently, it has been shown that chronic administration of benfotiamine, a precursor of thiamine, in a mouse model of AD (APP/PS1 mice) significantly reduced key features of this disease namely memory impairment, β-amyloid accumulation and tau hyperphosphorylation. However, it is unclear whether the observed effects are mediated by an unknown degradation product of benfotiamine or by phosphorylated derivatives synthesized from thiamine in neurons. We investigated whether benfotiamine (200 mg/kg) or thiamine (200 mg/kg) orally administered in water to 3-month old C57BL wild-type mice for 2 weeks could affect hippocampus and cortex-dependant memory and hippocampal cell proliferation. Memory extinction of contextual fear conditioning was significantly enhanced by both treatments. On the other hand, the amount of Ki67- and BrdU-positive cells was increased in the dentate gyrus of benfotiamine-treated mice when examined 5 days after the BrdU injection. In comparison, the number of positive cells in thiamine-treated mice was not different from the control. Although benfotiamine and thiamine seem both able to enhance memory, only benfotiamine stimulated cell proliferation. These results can be explained by a higher bioavailability of benfotiamine than thiamine and could account for the beneficial effects of this compound in a mouse model of Alzheimer’s disease. Keywords: Alzheimer Disease, benfotiamine, Cell Proliferation, thiamine and derivatives, Memory Conference: Belgian Brain Council, Liège, Belgium, 27 Oct - 27 Oct, 2012. Presentation Type: Poster Presentation Topic: Higher Brain Functions in health and disease: cognition and memory Citation: Vignisse J, Caron N, Markova N, Revishchin A, Wins P, Bachurin S, Steinbusch HW, Strekalova T and Bettendorff L (2012). Extinction of fear memory and cell proliferation in adult mouse hippocampus are increased by benfotiamine. Conference Abstract: Belgian Brain Council. doi: 10.3389/conf.fnhum.2012.210.00014 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 10 Sep 2012; Published Online: 12 Sep 2012. * Correspondence: Miss. Julie Vignisse, University of Liege, GIGA-Neurosciences, Liège, 4000, Belgium, julievignisse@gmail.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Julie Vignisse Nicolas Caron Natalia Markova Alexander Revishchin Pierre Wins Sergej Bachurin Harry W Steinbusch Tatyana Strekalova Lucien Bettendorff Google Julie Vignisse Nicolas Caron Natalia Markova Alexander Revishchin Pierre Wins Sergej Bachurin Harry W Steinbusch Tatyana Strekalova Lucien Bettendorff Google Scholar Julie Vignisse Nicolas Caron Natalia Markova Alexander Revishchin Pierre Wins Sergej Bachurin Harry W Steinbusch Tatyana Strekalova Lucien Bettendorff PubMed Julie Vignisse Nicolas Caron Natalia Markova Alexander Revishchin Pierre Wins Sergej Bachurin Harry W Steinbusch Tatyana Strekalova Lucien Bettendorff Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.