Abstract

Hollow-sphere-shaped nanocapsules containing intentionally inserted magnetic nanoparticles and predefined anticancer drugs provide a powerful magnetic vector under moderate gradient magnetic fields. They enable the nanocapsules to penetrate into the tumors and allow a controlled on-off switchable release of the anticancer drug cargo inside the tunors by remotely applied RF magnetic field. This smart drug delivery system, which can also be made imageable, is compact in geometry because the drug molecules and magnetic nanoparticles can all be self-contained within ∼150 nm capsules. In vitro results indicate that the nanocapsules are effective in reducing tumor cell growth.

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